When ferrets experience a prolapsed rectum, one or two things generally cause it:
There may not be enough water in their diet – the food should really be wet down (one part food to three parts water). We do not recommend feeding any cat food.
Another reason is a bacterial or viral infection that will cause the ferret to have a runny stool and cause them to strain.
Besides really wetting down the food, we recommend using an antibiotic (Clavamox, Cefa-Drops or Baytril). This will prevent any infection to the exposed area. Dosage should be .1 ml every 12 hours or as instructed by your veterinarian.
Keep the area clean and put on some Preparation H to soothe it.
Using Marshall Furo-Vite high-calorie vitamin supplement will help keep the ferret healthy during this period.